Can High Dose Vitamin D Supplementation Improve Semen Quality in Infertile Men?
With the deepening of research, it is found that vitamin D is actually a multi-functional signal molecule, and its target organs are many, including testis, sperm, male reproductive system, which are closely related to male infertility. The level of serum vitamin D in pregnancy is also related to premature delivery, overdue delivery, preeclampsia, and gestational diabetes.
Vitamin D receptor and vitamin D-related metabolizing enzymes widely exist in the male reproductive system. Animal experiments also confirmed that the sperm quality and reproductive capacity of mice lacking vitamin D decreased. Lack of vitamin D will lead to the decline of sperm motility, which has been confirmed by many studies, but the specific mechanism of affecting sperm is still unclear.
Recently, a study on the effects of vitamin D and calcium supplementation on semen quality of infertile men with low serum 25 hydroxyvitamin D showed that vitamin D supplementation could promote male reproductive capacity.
The study was a single-center, three blind, randomized clinical trials in which 1427 infertile men were screened, ,and 330 infertile men were included in the study. Subjects in the treatment group received 300000 units of cholecalciferol initially followed by 1400 units of cholecalciferol + 500mg of calcium per day for 150 days, while the other group received a placebo.
The results showed that the spontaneous pregnancy rate of men treated with vitamin D and calcium increased, but it was not related to the change of semen parameters. Compared with the control group, vitamin D supplementation in oligospermia patients increased the probability of live birth (35.6% vs. 18.3%).
The final conclusion is that although high dose vitamin D supplementation can not improve the semen quality of infertile men with vitamin D deficiency, vitamin D supplementation has a positive impact on oligospermia men, and also has a positive clinical significance in improving the fetal birth rate of men with vitamin D deficiency.
In addition to the congenital azoospermia and sperm deficiency, the causes of oligozoospermia can also be caused by many factors, such as acquired dystrophy, drug damage, varicocele, cryptorchidism and accidental testicular damage, which may cause diseases, and then male infertility.
If a man finds oligozoospermia, he must take timely treatment measures to avoid the deterioration of the disease-causing real male infertility and irreparable damage to the family. For men with oligospermia and asthenospermia, it is recommended to go to the hospital for relevant examination to make clear what causes it, and then further treatment.
The efficacy of drug treatment for oligospermia depends on the specific condition of the patient. If the patient is found to have prostatitis, seminal vesiculitis, orchitis, hemospermia caused by oligospermia, he can take Diuretic and Anti-inflammatory Pill for treatment. It can effectively eliminate the inflammation, restore the normal level of sperm, enhance the immunity of patients, and improve the pregnancy rate, which is a great choice.
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