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Can White Willow Bark Extract Treat Orchitis?

White willow bark extract is a kind of bark extract taking Salicin as a standard, which has been used as anti-inflammation, antipyretic, and analgesic for thousands of years. Although it has been used for a long time in human history, there are few related animal and human studies. A total of five human clinical studies and several animal studies have been carried out.
In general, the results of these studies support the analgesic and anti-inflammatory activities of the extract from white willow bark. In recent years, a variety of in vitro and animal studies have shown that the anti-inflammatory activity of white willow bark extract is related to the downregulation of inflammatory mediators TNF α and NF B.
Although Salicin is usually used as a standard as the extract of white willow bark, other components of the extract, including other salicylates, polyphenols and flavonoids, can also play a significant role in the treatment. Compared with nonsteroidal anti-inflammatory drugs, including aspirin that is usually used to relieve the pain symptoms of bacterial orchitis, the adverse effects of white willow bark extract are less.
In addition, the dosage of Salicin in the extract of Salix bark is 120-240mg, and its commonly used clinical dosage is lower than that of aspirin, which is 500mg. This difference may be due to the presence of polyphenols and flavonoids in the extract, which plays a beneficial role. The antioxidant and free radical scavenging properties of polyphenols and flavonoids in the extract of white willow bark are well known.
In recent years, a series of in vitro studies have evaluated the mechanism of action of white willow bark extracts and fractions. Modern medical research has proved that inflammation, pain, swelling, and other external reactions, aging of tissues and organs, are all related to excess free radicals.

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